| Sat, May 25 | |||
| Time | Teams | Records | View |
| 7:00 PM ET |
Portland @D.C. United |
4-1-7 (1-0-5 V) 1-8-2 (1-4-1 H) |
Matchup |
| 7:00 PM ET |
Philadelphia @Montreal |
5-4-3 (3-2-1 V) 6-2-2 (4-0-1 H) |
Matchup |
| 7:30 PM ET |
Toronto FC @New England |
1-6-4 (0-4-1 V) 3-4-4 (1-2-2 H) |
Matchup |
| 8:30 PM ET |
San Jose @FC Dallas |
3-4-6 (0-3-2 V) 7-2-3 (6-0-1 H) |
Matchup |
| 9:00 PM ET |
Chivas USA @Colorado |
3-6-2 (1-3-1 V) 4-4-4 (2-2-1 H) |
Matchup |
| 9:00 PM ET |
Chicago @Real Salt Lake |
2-7-1 (0-4-1 V) 6-5-2 (3-1-1 H) |
Matchup |
| Sun, May 26 | |||
| Time | Teams | Records | View |
| 3:30 PM ET |
Houston @Sporting Kansas City |
6-4-2 (2-2-1 V) 6-4-3 (3-2-1 H) |
Matchup |
| 5:00 PM ET |
Columbus @New York |
4-4-3 (3-2-1 V) 7-4-3 (4-1-1 H) |
Matchup |
| 11:00 PM ET |
Seattle @Los Angeles |
4-3-3 (2-2-1 V) 5-4-2 (3-1-1 H) |
Matchup |